Cytocompatibility of N-quaternary phosphonium chitosan derivatives

G. C. Lai; Z. H. Cai; C. H. Chen; C. H. Jou

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Cytocompatibility of N-quaternary phosphonium chitosan derivatives

四級鏻化幾丁聚醣衍生物之細胞相容性

G. C. Lai 蔡宗翰 ✉ Department of Materials and Textiles, Oriental Institute of Technology
Z. H. Cai 賴冠呈 Department of Materials and Textiles, Oriental Institute of Technology
C. H. Chen 陳建興 Department of Materials and Textiles, Oriental Institute of Technology
C. H. Jou 周啟雄 Department of Materials and Textiles, Oriental Institute of Technology

Abstract

In this study, we used chitosan to react with 2 kinds of N-(carboxyalkyl) triphenylphosphonium bromide compounds (CATPPs)to obtain two kinds of N-quaternary phosphoniun chitosan derivatives (NQPCS). The cytocompatibility were tested by using L929fibroblasts to evaluate the medicine effect for proliferation and cytotoxicity. This project is about to prove the medicine NQPCS can be applied in textiles, cosmetic and biomedical fields.

Keywords

摘要

本研究是利用幾丁聚醣分別與2種N-(羧烷基)三苯基溴化鏻化合物(CATPPs)反應而得2種四級鏻化幾丁聚醣衍生物(NQPCS)。利用L929纖維母細胞來評估藥物對於其細胞成長活性與細胞毒性，並以此實驗測得其細胞相容性。本研究證明所合成之藥物NQPCS能應用於紡織領域、化妝品及生物醫學等用途。

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Issue: Vol. 27 No. 7 (2020)
Section: Original Research Articles
Pages: 456-459
Submitted: 2020-11-11
Published: 2021-01-05
ID: JHGT-20-647
Views: 1
Downloads: 0

引用 How to cite

Lai, G. C., Cai, Z. H., Chen, C. H., & Jou, C. H. (2020). Cytocompatibility of N-quaternary phosphonium chitosan derivatives. Journal of the Hwa Gang Textile, 27(7), 456-459. https://jhgt.org.tw/article/view/421

@article{lai2020_421,
  author  = {Lai, G. C. and Cai, Z. H. and Chen, C. H. and Jou, C. H.},
  title   = {Cytocompatibility of N-quaternary phosphonium chitosan derivatives},
  journal = {Journal of the Hwa Gang Textile},
  year    = {2020},
  volume  = {27},
  number  = {7},
  pages   = {456--459},
  issn    = {1025-9678},
  url     = {https://jhgt.org.tw/article/view/421}
}

TY  - JOUR
AU  - Lai, G. C.
AU  - Cai, Z. H.
AU  - Chen, C. H.
AU  - Jou, C. H.
TI  - Cytocompatibility of N-quaternary phosphonium chitosan derivatives
JO  - Journal of the Hwa Gang Textile
T2  - 華岡紡織期刊
VL  - 27
IS  - 7
PY  - 2020
SP  - 456
EP  - 459
KW  - chitosan
KW  - L929 fibroblast
KW  - cytocompatibility
SN  - 1025-9678
UR  - https://jhgt.org.tw/article/view/421
AB  - In this study, we used chitosan to react with 2 kinds of N-(carboxyalkyl) triphenylphosphonium bromide compounds (CATPPs)to obtain two kinds of N-quaternary phosphoniun chitosan derivatives (NQPCS). The cytocompatibility were tested by using L929fibroblasts to evaluate the medicine effect for proliferation and cytotoxicity. This project is about to prove the medicine NQPCS can be applied in textiles, cosmetic and biomedical fields.
ER  -

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